The New Reality of Cancer
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By Dr. Silver, MD, and Dr. Lindmeier, DHSc
THE MOST COMPREHENSIVE PEER-REVIEWED INTEGRATIVE ONCOLOGY BOOK EVER WRITTEN
The authoritative guide to cancer testing and treatment, conventional and integrative, from around the world.
- 39 chapters, nearly 600 pages
- More than 120 color illustrations
- Every fact backed by a numbered peer-reviewed reference
- Written by a physician with nearly 50 years in medicine who is a 25-year cancer survivor
The full-color paperback edition is coming soon to Amazon.
WHAT’S IN THE BOOK
Understand your cancer
- What cancer is, in plain language
- What your stage and pathology report really mean
- The most important decisions in the first two weeks after diagnosis
- Where to get a second opinion
Find out why it grew
- Why cancer grows in one person and not another
- Toxins linked to cancer: heavy metals, pesticides, chemicals and EMFs
- Why some bodies can’t clear toxins
- How sugar, insulin and inflammation help cancer grow
- What your tumor uses for fuel
- Hidden infections: viruses, mold, parasites, root canals and jaw infections
What you can start today
- How to make your home safer: water, air and household products
- What to eat, including a plant-based ketogenic plan
- Exercise, sleep and stress
- How to prevent and treat the side effects of chemo, radiation and immunotherapy
GET THE RIGHT TESTS
- The tests you must arrange before surgery or your first treatment
- Tumor DNA and RNA testing to find what drives your cancer
- Blood tests that detect cancer DNA and cancer cells
- Genetic tests that show how your body handles chemo drugs
- A complete checkup of your body’s “terrain”
- Tests that show how well your immune system can fight
- Testing your own living cancer cells to see which chemo drugs and natural compounds kill them
- Testing in Germany, Greece, India and other countries
Tests named in the book include
- Signatera
- Guardant360
- FoundationOne
- Caris
- Tempus
- Galleri
- Oncotype DX
- MammaPrint
- Decipher
- CellSearch
- RGCC
- Datar
- Biofocus
- maintrac
- and many more
EVERY TREATMENT OPTION
- Surgery
- Low-dose versus high-dose chemotherapy
- Radiation, including the newest types used worldwide
- Heat therapy (hyperthermia) and freezing therapy (cryoablation)
- Ultrasound, light and electric-field therapies, including PEMF
- Oxygen, ozone and hyperbaric oxygen
- Injecting treatment directly into the tumor
- Targeted drugs and hormone therapy, and what to do when they stop working
- Immunotherapy of every type, including CAR-T cells, NK cells and cancer vaccines
- How to reverse drug resistance
- How to help prevent cancer from spreading
BLOCK YOUR CANCER’S PATHWAYS
Every cancer runs on a few switches that are stuck “on.” These switches are called pathways. This book shows you:
- The 21 families of cancer pathways, explained in plain language
- How DNA, RNA and live-cell testing show which pathways your cancer is using
- Which drugs, vitamins, herbs and mushrooms block each pathway, with a table for every family
- How far each one has been studied in people
- How to block different pathways instead of the same one twice
- The few combinations to avoid
- How to use all of it alongside chemo, radiation, surgery and immunotherapy
The 21 pathway families
- Growth signals (EGFR, HER2, IGF-1)
- The relays inside the cell (RAS, PI3K/AKT/mTOR, STAT3)
- Cancer stem cell pathways (Hedgehog, Wnt, Notch, TGF-beta)
- How cancer cells divide
- How cancer cells avoid dying
- DNA repair (BRCA and PARP)
- Metabolism: sugar, glutamine, fat and the mitochondria
- Inflammation and oxygen (NF-kB, COX-2, HIF, VEGF)
- Hormones: estrogen, testosterone and cortisol
- Epigenetics: how genes are switched on and off
- How cancer hides from the immune system
- New blood vessels that feed the tumor
- Invasion and spread
- Immortality (telomeres)
- Protein disposal
- “Zombie” (senescent) cells
- Sleeping (dormant) cancer cells
- The microbiome
- Nerves and stress signals
- Electrical signals
- The body clock
MORE THAN 50 REPURPOSED DRUGS
Old, inexpensive drugs approved for other illnesses and studied against cancer. Read our guide to repurposed drugs for cancer.
Antiparasitic drugs
- Ivermectin
- Mebendazole
- Fenbendazole
- Albendazole
- Niclosamide
- Nitazoxanide
- Pyrvinium
- Moxidectin
- Praziquantel
Antimalarial drugs
- Hydroxychloroquine
- Chloroquine
- Artesunate
- Atovaquone
Antibiotics and antifungals
- Doxycycline
- Clarithromycin
- Itraconazole
Diabetes drugs
- Metformin
- GLP-1 drugs
- SGLT2 drugs
Heart, blood pressure and cholesterol drugs
- Statins
- Fenofibrate
- Losartan
- Propranolol
- Digoxin
- Dipyridamole
- Heparins
- Pentoxifylline
Anti-inflammatory and pain drugs
- Aspirin
- Celecoxib
- Colchicine
- Sulfasalazine
- Lidocaine
Other repurposed drugs
- Rapamycin
- Tadalafil
- Sildenafil
- Low-dose naltrexone
- Cimetidine
- Disulfiram
- Dichloroacetate (DCA)
- Valproic acid
- Zoledronic acid
- Melatonin
- and more
VITAMINS, MINERALS AND ANTIOXIDANTS
Vitamins and minerals
- Vitamin D
- Vitamin A
- Vitamin K2
- Vitamin E family
- Vitamin B3 (nicotinamide)
- Vitamin B1
- Folate
- Vitamin B12
- Selenium
- Zinc
- Magnesium
- Iodine
- Iron
- Calcium
- Copper lowering
Antioxidants and peptides
- High-dose IV vitamin C
- Alpha-lipoic acid
- Coenzyme Q10
- Natural vitamin E
- Thymalfasin
- PNC-27
- MOTS-c
PLANT COMPOUNDS AND HERBS
From foods and spices
- Curcumin (turmeric)
- Green tea (EGCG)
- Broccoli sprouts (sulforaphane)
- Ginger
- Garlic
- Rosemary
- Black seed
- Pomegranate
- Lycopene
- Flaxseed
- Soy
Purified plant compounds
- Berberine
- Quercetin
- Fisetin
- Apigenin
- Luteolin
- Resveratrol
- Pterostilbene
- Honokiol
- DIM
- Milk thistle
- Boswellia (frankincense)
Herbs from around the world
- Mistletoe
- Astragalus
- Ginseng
- Ashwagandha
- Andrographis
- Cat’s claw
- Holy basil
- Guduchi
- Neem
- Guggul
- Danshen
- Scutellaria
- Triptolide
- Elemene
- Coix seed oil
- Huaier
- Pygeum
- Black cohosh
- Triphala
- Essiac
Traditional systems
- Chinese herbal formulas
- Japanese Kampo formulas
- Ayurvedic formulas
- Homeopathy
- German biological medicine
MUSHROOMS AND NATURAL IMMUNE AGENTS
- Turkey tail (PSK)
- Shiitake (lentinan, AHCC)
- Reishi
- Maitake
- Cordyceps
- Chaga
- Lion’s mane
- Agaricus blazei
- Phellinus linteus
- Beta-glucans
- MGN-3
- IP6
- Lactoferrin
- Modified citrus pectin
- Colostrum
- Shark liver oil
- Probiotics
- Coffee enemas
For every drug, vitamin, herb and mushroom, the book tells you:
- How it works
- Which pathways it blocks
- What studies in people show
- The doses used in studies
- Drug interactions
STAYING WELL FOR THE LONG RUN
- How often to have blood tests and scans
- PET, CT and MRI explained
- Clinical trials
- Products to avoid: everything with documented harm, in one place
- New treatments to watch
ALSO INSIDE
- Dr. Silver, MD, tells his own cancer story and how he recovered
- A guide for caregivers
- A glossary of medical terms, full references and an index
- No financial ties to any lab, drug company, supplement maker or clinic
COMPLETE TABLE OF CONTENTS
Front of the book
- Disclaimer
- Preface
- Introduction: Why We Wrote This Book
- How to Use This Book
Part One — What You Have
- 1. What Cancer Actually Is
- 2. What Your Stage Does and Doesn’t Tell You
- 3. The First Two Weeks
Part Two — Why It Grew in You
- 4. The Terrain
- 5. What Came at You, and Why You Couldn’t Clear It
- 6. Inflammation and Insulin
- 7. The Tumor’s Fuel
- 8. Chronic Infection, Including the Mouth
Part Three — What You Can Do Now
- 9. Food, Water, and Air: Is Your House Toxic?
- 10. Movement, Sleep, Stress, and Mind–Body Medicine
- 11. Side Effects of Chemotherapy, Radiation, and Immunotherapy: Preventing and Treating Them
Part Four — The Tests That Change Decisions
- 12. Before You Test: The Four Questions and the Windows That Close
- 13. Sequencing Your Tumor
- 14. Reading Cancer in the Blood
- 15. Inherited Risk
- 16. Testing the Terrain
- 17. Immune Profiling and the Tumor Microenvironment
- 18. Asking the Cells Directly
- 19. Testing Outside the United States
Part Five — Treatment
- 20. Surgery and the Decisions Around It
- 21. Chemotherapy: Metronomic, Potentiated, and Maximum Tolerated Dose
- 22. Radiation
- 23. Heat, Cold, Light, and Sound
- 24. Electricity and Voltage
- 25. Oxygen, Ozone, and Hydrogen Peroxide
- 26. Direct Injection Into the Tumor
- 27. Targeted Therapy and What to Do When It Stops Working
- 28. Immunotherapy
- 29. Reversing Resistance
- 30. Preventing Metastasis: The Pre-Metastatic Niche and How to Block It
- 31. Your Cancer Pathways
- 32. Repurposed Cancer Drugs
- 33. Vitamins and Minerals
- 34. Antioxidants in Cancer Care
- 35. Plant Compounds and Herbs
- 36. Mushrooms and Natural Immune Agents
- 37. Integrative Care Alongside Standard Treatment
Part Six — The Long Run
- 38. Monitoring and Building Your Plan
- 39. What to Keep Out of Your Plan
Back of the book
- Epilogue
- The Watch List
- Glossary
- References
- Index
LOOK INSIDE
A sample from Chapter 31, one of the 21 pathway tables in the book. This table covers the relays inside the cell: RAS, PI3K/AKT/mTOR and STAT3.
| Agent | What it blocks or switches on | Studied in people? |
|---|---|---|
| Metformin | Switches off mTOR through AMPK | Randomized trials |
| Rapamycin (sirolimus) | Blocks mTOR | Randomized trial (skin cancer prevention in transplant patients) |
| Statins | Remove the anchor RAS needs | Randomized trials |
| Ivermectin | Blocks PAK1/AKT/mTOR | Laboratory and animal |
| Curcumin | Blocks STAT3 | Randomized trials |
| Berberine | Dampens mTOR and insulin signaling | Randomized trial (polyp prevention) |
| Quercetin | Blocks PI3K | Small human studies |
| Milk thistle (silibinin) | Blocks STAT3 | Small human studies |
From Table 31.2 of The New Reality of Cancer. In the book, each agent’s doses, interactions and studies are described in full in its own chapter.
Coming Soon
The New Reality of Breast Cancer
The Science of Recovery
The companion volume to The New Reality of Cancer, by Dr. Silver, MD, and Dr. Lindmeier, DHSc.
ABOUT THE AUTHORS
Dr. Silver, MD, graduated from Temple University School of Medicine. He then completed a three-year internal medicine residency at Albert Einstein Medical Center, followed by a two-year invasive cardiology fellowship at the Deborah Heart and Lung Center. He has practiced medicine for nearly fifty years and has taught physician-to-physician programs in integrative oncology internationally. Dr. Silver is trained in all aspects of integrative medicine, including integrative oncology, anti-aging medicine, ozone therapy, low-dose potentiated chemotherapy, autoimmune disease and Lyme disease. He wrote this book to help others with cancer. He is a 25-year cancer survivor.
“I had radiation exposure in the cardiac cath lab and ended up with lymphoma that took me three years to cure. I still have low immunity, and I continue to take all my medications and to use my PEMF, my Rife frequency device, hyperbaric oxygen and many other modalities discussed in this book. This book has been written for one reason: to help cancer patients get well.”
— Dr. Silver, MD
Dr. Lindmeier, DHSc, earned her Doctor of Health Science degree from Nova Southeastern University in 2025 and completed her practicum in integrative oncology. She works with cancer patients around the world as a cancer educator and advocate, helping people understand their records, testing options, and the broad landscape of conventional and integrative cancer care.
Cancer Expert MD, Dr. Silver, MD, and Dr. Lindmeier, DHSc, have no financial relationship of any kind with any laboratory, testing facility, pharmaceutical company, device maker, supplement company, clinic or hospital.
FREQUENTLY ASKED QUESTIONS
Who is this book for?
Patients and families facing a cancer diagnosis who want to understand the full range of testing and treatment options, and healthcare professionals interested in integrative oncology.
What is integrative oncology?
Integrative oncology combines conventional cancer treatment with evidence-informed complementary approaches, such as metabolic strategies, repurposed drugs and natural compounds, used alongside standard care rather than instead of it.
Is the book available in print?
The digital edition is available now. The full-color paperback is coming soon to Amazon.
Is the book based on research?
Yes. It includes numbered references to peer-reviewed studies throughout, along with original color illustrations.
This book and website are for education only. They are not medical advice and do not diagnose or treat any condition.